PROJECT SUMMARY/ABSTRACT Training creative and productive investigators in gastrointestinal research is the central mission of our program. Emerging discoveries in human genetics, epigenetics, molecular and cellular biology, single cell sequencing technologies, microbiology, immunology, and epidemiology have had major impacts on the understanding of pathophysiology of gastrointestinal diseases. Accordingly, our T32 program is focused on training MD, MD/PhD, and PhD investigators in basic and clinical research in the pathophysiology of GI diseases. During This funding cycle, we have successfully recruited investigators from diverse personal and professional backgrounds. This supplement is intended to provide support for one of these talented trainees.