Project Summary This Administrative Supplement proposes continuation of all major activities of the OK-INBRE program for an additional 10 months (5/1/24 – 2/28/25), including the Administrative Core, Bioinformatics Core, Proteomics Core, Developmental Research Project Program (continuation of current active Research and Pilot Project Leaders) and Alteration and Renovation. This supplemental application for the Oklahoma IDeA Network for Biomedical Research Excellence (OK-INBRE) outlines how we will further enhance the statewide research infrastructure and biomedical research capacity in Oklahoma by: (i) enhancing and strengthening the research culture and building biomedical research capacity and research infrastructure at network institutions; (ii) providing support for faculty research and research mentoring to strengthen biomedical research excellence and expertise throughout Oklahoma; and (iii) providing research opportunities for students to help develop a strong biomedical research workforce in Oklahoma. The statewide OK-INBRE network includes two research intensive institutions, Langston University, the only Historically Black University in Oklahoma, and Northeastern State University, a PUI with one of the highest numbers of American Indians of four-year colleges in the nation. Additionally, Oklahoma’s only accredited tribal college, along with four other PUIs and three additional community colleges are included that educate large numbers of students from underrepresented groups. OK-INBRE will provide continuation of six significant research project investigator (RPI) awards that are currently approved. Specific career development mentors will help the RPI awardees achieve scientific independence. In addition, currently approved pilot project grant awards will continue for five PUI pilot project awardees. Equipment awards will be provided through a peer-reviewed grant selection committee for PUI and CC applications. Support for 35 undergraduate students also will be supported through a vibrant and dynamic summer undergraduate research program. OK-INBRE will also support Bioinformatics and Proteomics Core facilities that will serve as statewide research and educational resources to provide faculty, trainees, and students throughout the state with access to the computational tools needed to enhance multidisciplinary biomedical research in Oklahoma. Uniquely, the Proteomics Core will not only play a central role in training the next generation of researchers in Oklahoma, but it will also be used as a resource for investigators in all IDeA-eligible states. An alteration and renovation project at TCC will be undertaken to enhance and expand student training by transforming currently unused space into new laboratory and experiential teaching facilities. Finally, through an undergraduate research program; multiple workshops and seminars; research mentoring; and access to state-of-the-art core facilities; the OK-INBRE program will continue to enhan...