Project Summary Abstract This diversity supplement will provide Ms. Jania Zenon with invaluable mentorship, training, and advanced research experience via the recently funded recently awarded NIH grant entitled "Variations in long-term fine particulate matter (PM2.5) air pollution associations with mortality by particle size, source, and composition" (R01ES035468). The research portion of this supplement aims to expand this research to investigate mortality impacts of PM2.5 air pollution exposures on mortality from Alzheimer’s disease. PM2.5 has been found to be associated with serious adverse health implications, including increased risk of mortality. However, there is a limited understanding with respect to effects on neurodegenerative disorders. Specifically, while there is evidence of an association between PM2.5 and Alzheimer’s disease, there is a lack of rigorous research on PM2.5 and Alzheimer’s disease mortality; and there is even more limited research on the impacts of PM2.5 particle source, size distribution or composition-specific variations in the PM2.5 mass- Alzheimer’s association. The parent grant focuses on the linkage between variation in PM2.5 size, composition, source and cardiovascular disease (CVD) mortality in the NIH-AARP Diet and Health Cohort. Ms. Zenon aims to assess these associations with respect to Alzheimer’s disease mortality in this well- characterized cohort of over 500,000 older aged participants throughout the United States, who have been followed since 1995-1996 for mortality and cause of death, individual characteristics of the participants, and census tract ecologic covariates. She will also assess the potentially effect modifying of an antioxidant rich diet and residence health opportunity disparities on these associations. This will enable an assessment of the various potential particulate matter air pollution exposure associations with Alzheimer’s disease mortality, as well as investigations into potentially modifiable PM2.5 effect varying factors.