# Vaccine induction of Salmonella-specific Th1 memory cells

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $225,839

## Abstract

PROJECT SUMMARY
A successful vaccine for systemic Salmonella infections will need to induce Th1 memory cells, but the tissue
location and required functionality of these cells is poorly understood. Our preliminary data show that liver
Tissue Resident Memory (TRM) CD4 T cells express higher levels of IL-18R and are more protective than the
corresponding TRMs cells in the lamina propria. In this application, we will test, (i) whether IL-18R expression
allows non-cognate responsiveness and robust TRM-mediated protection, and (ii) whether the use of a mRNA
nanoparticle delivery system can induce this protective population in the liver of vaccinated mice.

## Key facts

- **NIH application ID:** 11031610
- **Project number:** 1R21AI187632-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** STEPHEN J MCSORLEY
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $225,839
- **Award type:** 1
- **Project period:** 2024-09-26 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11031610

## Citation

> US National Institutes of Health, RePORTER application 11031610, Vaccine induction of Salmonella-specific Th1 memory cells (1R21AI187632-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11031610. Licensed CC0.

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