# Delaware INBRE

> **NIH NIH P20** · UNIVERSITY OF DELAWARE · 2024 · $180,454

## Abstract

PROJECT SUMMARY/ABSTRACT
The aim of this project is to acquire a Particle Metrix ZetaView QUATT to characterize small vesicles and
particles by nanoparticle tracking analysis (NTA). The University of Delaware (UD) Bio-Imaging Center and its
satellite Flow Cytometry Core currently provide nanoparticle characterization of extracellular vesicles (EVs),
viruses, virus-like particles, and other nanoparticles used for drug delivery with electron microscopy and flow
cytometry. These approaches are invariably complemented and/or validated by NTA to determine size
distribution, concentration, and zeta-potential. Despite the ubiquity of the NTA approach, there are currently no
NTA systems in a fee-for-service core facility in Delaware. This project aims to fill this critical gap in capabilities
by placing the ZetaView NTA system in the UD Bio-Imaging Center, which will ensure that it is easily
accessible and well-maintained by core facility staff scientists. Bio-Imaging Center staff will also train users
how to run their own samples on the ZetaView and also provide NTA on the ZetaView as an “add-on” service
for individuals submitting EV or nanoparticle samples for electron microscopy and flow cytometry services.
Therefore, the ZetaView will directly complement recent investments in these technologies and further advance
our ability to support research on EV release in bone marrow cells, cancer cells, pathogenic microbes, and
nanoparticles developed from viruses, assembled peptides, and fabricated nano-vesicles.

## Key facts

- **NIH application ID:** 11033261
- **Project number:** 3P20GM103446-23S7
- **Recipient organization:** UNIVERSITY OF DELAWARE
- **Principal Investigator:** MELINDA K DUNCAN
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $180,454
- **Award type:** 3
- **Project period:** 2001-09-30 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11033261

## Citation

> US National Institutes of Health, RePORTER application 11033261, Delaware INBRE (3P20GM103446-23S7). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/11033261. Licensed CC0.

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