# Mechanisms of chromatin and transcriptional regulation

> **NIH NIH R35** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $86,867

## Abstract

Abstract of Parent Award
Our long-term goal has been to reveal the molecular mechanisms of histone-modifying
enzymes, histone chaperones and other transcriptional regulators that control genome
function. Many of the proteins and their modifications we study are dysregulated in human
disease, including cancer. Despite considerable progress by our lab and others, crucial
knowledge gaps remain in our fundamental understanding of chromatin regulation. With
the renewal of this MIRA award, we will continue our studies into the function of chromatin
regulators and address three of the foremost fundamental questions in chromatin biology:
1) How do histone-modifying enzymes and chaperones contribute to chromatin
organization and gene transcription? 2) How do more recently discovered histone PTMs
and reader domains contribute to gene transcription? 3) What are the rules by which
histone readers engage nucleosomes and how do these binding events regulate
downstream events in chromatin? For each question, we highlight several examples of
the types of studies we are pursuing and describe how they will advance the field.

## Key facts

- **NIH application ID:** 11034556
- **Project number:** 3R35GM126900-07S1
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Brian D Strahl
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $86,867
- **Award type:** 3
- **Project period:** 2018-05-01 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11034556

## Citation

> US National Institutes of Health, RePORTER application 11034556, Mechanisms of chromatin and transcriptional regulation (3R35GM126900-07S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/11034556. Licensed CC0.

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