# Dynamic architecture and function of microtubule networks

> **NIH NIH R35** · VANDERBILT UNIVERSITY · 2024 · $249,971

## Abstract

Project Summary
I request funds to purchase several key components in order to add an advanced functionality of
an existing live-cell imaging microscope system. Specifically, I propose to add an NSPARC
(confocal multi-array detector) to the Nikon Eclipse Ti2 microscope system currently equipped for
Total Internal Reflection Fluorescence (TIRF) microscopy. This would allow for low-light 3D
detection of ultra-fine structural information beyond the resolution limit. This additional microscope
capacity will allow for super-resolution imaging of subcellular dynamics in live samples of various
thickness, including single cells and multicellular tissue samples. This equipment is needed to
achieve goals of the parent grant with deep insights and a cutting-edge data quality.

## Key facts

- **NIH application ID:** 11037439
- **Project number:** 3R35GM127098-07S1
- **Recipient organization:** VANDERBILT UNIVERSITY
- **Principal Investigator:** Irina Kaverina
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $249,971
- **Award type:** 3
- **Project period:** 2018-04-01 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11037439

## Citation

> US National Institutes of Health, RePORTER application 11037439, Dynamic architecture and function of microtubule networks (3R35GM127098-07S1). Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/grant/nih/11037439. Licensed CC0.

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