# Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $1,715,157

## Abstract

Project Summary
The proposed study will investigate brain imaging markers of a small brainstem nucleus called the locus
coeruleus, which is important for cognitive function and is the first brain region to show Alzheimer’s disease-
related changes in older adults who go on develop dementia. The study will examine brain imaging locus
coeruleus markers in older adults who go on to have a healthy aging experience over time and in those who go
on to develop Alzheimer’s disease, cerebrovascular disease and cognitive decline. By comparing the trajectory
of changes in brain imaging markers of the locus coeruleus, we can better understand the potential value of
these imaging markers for tracking disease progression from a very early stage.

## Key facts

- **NIH application ID:** 11040937
- **Project number:** 7R01AG082073-02
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Mark W Bondi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,715,157
- **Award type:** 7
- **Project period:** 2023-04-01 → 2028-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11040937

## Citation

> US National Institutes of Health, RePORTER application 11040937, Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline (7R01AG082073-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11040937. Licensed CC0.

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