# Administrative Supplement to Deciphering dopaminergic circuits required for food anticipatory activity in mice

> **NIH NIH R16** · CALIFORNIA STATE POLY U POMONA · 2024 · $84,148

## Abstract

Project Summary/Abstract
Given the over-abundance of food in modern society, it is easy to lose sight of the importance of
feeding to animals in nature. For most animals, food is extremely scarce and being wise to
opportunities to eat is essential for survival. As such, the circadian system has evolved to
receive a number of different stimuli—i.e., light, temperature, food, and even fear—to keep
biological processes coordinated and allow for adaptation to ever changing conditions. The
ability to tell time relative to feeding has a long history of research, going back more than one
hundred years hundred years with behavioral observations of honeybees and rats. However, the
neural circuitry behind adaptation of behavior to timed feeding has continually escaped our
grasp. In this project, I will utilize conditional genetics, viral restorations, and chemogenetic tools
to identify the dopamine population (both anatomically and genetically) that is required for the
behavioral expression of food anticipatory activity in lab mice. From here, we will build out a
more comprehensive characterization of how a select population of dopamine neurons
projecting to the striatum can inform the time keeping systems of the brain that food is available.

## Key facts

- **NIH application ID:** 11041745
- **Project number:** 3R16GM145576-02S1
- **Recipient organization:** CALIFORNIA STATE POLY U POMONA
- **Principal Investigator:** Andrew David Steele
- **Activity code:** R16 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $84,148
- **Award type:** 3
- **Project period:** 2023-05-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11041745

## Citation

> US National Institutes of Health, RePORTER application 11041745, Administrative Supplement to Deciphering dopaminergic circuits required for food anticipatory activity in mice (3R16GM145576-02S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11041745. Licensed CC0.

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