This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management; pain The medicinal chemistry Consultant will be expected to provide executive (senior scientific)- level Medicinal Chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through video/tele conference and by email. The role of the medicinal chemistry Consultant may include but is not limited to the following responsibilities and tasks: 1. Offer input on project milestones, target product profiles, and testing funnels. 2. Provide feedback on chemical structures and processes proposed by a chemistry service Contractor for each round of SAR. 3. Evaluate SAR data on a weekly or biweekly basis. 4. Evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual Consultant and the needs of individual projects. 5. In partnership with other Consultants, Contractors, and the NIH staff, advise, strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies. 6. Serve as the medicinal chemistry expert in order to identify potential drug discovery and development challenges and suggest strategies to address these challenges. 7. Collaborate on design of investigative studies in support of NIH drug discovery and development projects. 8. Review Medicinal Chemistry sections of regulatory filings provided by CROs (Contract Research Organizations) or PIs (Principal Investigators). 9. Collaborate on the design of investigative studies in support of development compounds. 10. At the request of program manager, accompany NIH staff on visits to CRO facilities that provide research services to NIH programs including the NIH Helping to End Addiction Long-term (HEAL) and NIH Blueprint Neurotherapeutics Network. Assist NIH staff in inspecting CRO facilities, and prepare and submit trip reports to BPN and/or HEAL program managers if requested. 11. Discuss appropriateness of CRO’s proposed methodology. 12. Facilitate Lead Development Team discussions via telephone and email regarding assigned medicinal chemistry efforts.