# EFFICACY AND SAFETY EVALUATION OF A LEAD GENE THERAPY CANDIDATE IN PROPIONIC ACIDEMIA (PA) DISEASE MOUSE MODELS AND BIOANALYTICAL ASSAY METHODS DEVELOPMENT.

> **NIH NIH N01** · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · 2024 · $51,059

## Abstract

The National Center for Advancing Translational Sciences (NCATS), through its Therapeutics for Rare and Neglected Diseases (TRND) program, is collaborating with the National Human Genome Research Institute (NHGRI) to advance an AAV9 Propionyl-CoA Carboxylase (PCCA) gene therapy candidate as a possible treatment for Propionic Acidemia (PA). The overall objective of this task order is for the contractor to evaluate the efficacy and safety of an Adeno-associated virus 9 (AAV9) Propionyl-CoA Carboxylase (PCCA) gene therapy candidate in propionic acidemia (PA) disease mouse models, previously developed at NHGRI, and develop bioanalytical assay methods that will be used to measure biodistribution and enzyme activity resulting from PCCA transgene expression.

## Key facts

- **NIH application ID:** 11042082
- **Project number:** 75N95019D00012-P00003-759502000005-1
- **Recipient organization:** LOVELACE BIOMEDICAL RESEARCH INSTITUTE
- **Principal Investigator:** MIKE ROBERTSON
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $51,059
- **Award type:** —
- **Project period:** 2020-09-25 → 2024-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11042082

## Citation

> US National Institutes of Health, RePORTER application 11042082, EFFICACY AND SAFETY EVALUATION OF A LEAD GENE THERAPY CANDIDATE IN PROPIONIC ACIDEMIA (PA) DISEASE MOUSE MODELS AND BIOANALYTICAL ASSAY METHODS DEVELOPMENT. (75N95019D00012-P00003-759502000005-1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/11042082. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*