# Skin-Adipose axis in HLA-II mouse models of Group A Streptococcus infection

> **NIH NIH P20** · UNIVERSITY OF NORTH DAKOTA · 2024 · $204,735

## Abstract

This proposal aims to establish proof of concept that i) downregulation of PPAR and impaired 
adipogenesis are a result of the dissemination of Group A Streptococcus (GAS) bacteria into the adipose 
niche during Necrotizing Soft Tissue Infections (NSTI), and ii) activation of PPAR by specific ligands might 
have a positive effect on reversing the impaired adipogenesis. Our studies aim to advance the 
understanding of the metabolic consequences and pathophysiological mechanisms underlying NSTI in 
varying genetic contexts for designing novel diagnostic and personalized therapeutic strategies to improve 
NSTI outcomes. The information gained from the proposed studies will present us with knowledge of hostdirected 
approaches as feasible adjuncts to antibiotic therapy and substantially transform the therapeutic 
strategies to promote favorable outcomes of NSTI and create healthy adipose tissue homeostasis.

## Key facts

- **NIH application ID:** 11042134
- **Project number:** 5P20GM113123-09
- **Recipient organization:** UNIVERSITY OF NORTH DAKOTA
- **Principal Investigator:** Catherine Ayn Brissette
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $204,735
- **Award type:** 5
- **Project period:** 2016-05-13 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11042134

## Citation

> US National Institutes of Health, RePORTER application 11042134, Skin-Adipose axis in HLA-II mouse models of Group A Streptococcus infection (5P20GM113123-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11042134. Licensed CC0.

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