# Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients > **NIH NIH R44** · TURING MEDICAL TECHNOLOGIES INC · 2024 · $1,500,000 ## Abstract Project Abstract/Summary The objective of this psychological technology SBIR/STTR Fast-Track proposal is to provide an innovative gamified biofeedback solution (software-only) to improve the effectiveness of functional Magnetic Resonance Imaging (fMRI) for pediatric pre-neurosurgical planning. Maximal safe resection of an epileptic focus to optimize outcome is carefully balanced against impact on critical brain regions that could result in neurodevelopmental deficits. To avoid deficits such as aphasia or paralysis, surgeons rely on pre-surgical functional brain mapping to define borders for safe resection. Gold standard, invasive functional brain mapping via electrocortical stimulation (ECS) is complex, time consuming and carries medical risks (e.g. seizures). It is extremely challenging for children, to tolerate the often-uncomfortable electrical stimulation. FDA cleared non- invasive fMRI is a safer alternative for functional mapping. Unfortunately, fMRI has yet to reach its full potential in pediatrics. Motion as low as 0.2 mm causes distortion of the fMRI signal. Clinical fMRI tasks are also performed covertly (i.e., no overt speech, no recording of button presses). Functional maps are generated post-hoc, so scan operators and patients cannot know if sufficient usable data were collected, resulting in 50- 90% clinical pediatric fMRI failure rates due to motion and poor task compliance. NOUS Imaging Inc. has developed FDA 510(k)-cleared Framewise Integrated Real-Time MRI Monitoring (FIRMM) software for tracking motion and its effects. Use of FIRMM can greatly improve the chances of obtaining usable fMRI maps, reducing fMRI data loss rates due to motion by >50% in children. FIRMM currently displays brain motion to the scan operator and patient in real-time, enabling scan operator intervention and patient self-regulation. In this Fast-Track application, we will extend development from FIRMM to FIRMM Qx with gamified biofeedback and task compliance tracking, to provide a new, neuro-developmentally appropriate, biofeedback-based quality improvement solution for pediatric clinical fMRI. In Phase I we will develop and verify FIRMM Qx as a tool to greatly reduce fMRI mapping failures due to non-compliance, motion or both. In Phase II, we will demonstrate that FIRMM Qx is superior to fMRI without real-time QC and biofeedback, providing more accurate maps and lower non-invasive brain mapping fail-rates for pediatric epilepsy surgery planning. NordicNeuroLab (NNL) is the leading supplier of fMRI hardware and software, used for fMRI at > 2000 institutions worldwide. However, NNL fMRI fails whenever insufficient quality fMRI data are collected. A new, synergistic partnership between NOUS and NNL will add FIRMM Qx real-time motion and task compliance improvement to NNL fMRI. NOUS will be providing developmental psychology know-how, while NNL provides best-in-class fMRI hardware, post- processing and a large distribution network. Adding FIRMM Qx, to the NOU... ## Key facts - **NIH application ID:** 11044939 - **Project number:** 4R44NS129521-03 - **Recipient organization:** TURING MEDICAL TECHNOLOGIES INC - **Principal Investigator:** Damien A Fair - **Activity code:** R44 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2024 - **Award amount:** $1,500,000 - **Award type:** 4N - **Project period:** 2022-09-20 → 2026-03-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/11044939 ## Citation > US National Institutes of Health, RePORTER application 11044939, Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients (4R44NS129521-03). Retrieved via AI Analytics 2026-07-07 from https://api.ai-analytics.org/grant/nih/11044939. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*