Project Summary. Clinical scientists from the University of Mississippi Medical Center and Mississippi State University in collaboration with Mississippi Center for Clinical and Translational Research and Mississippi Center of Excellence in Telehealth are leading this “team science” project that seeks to validate immersive virtual reality (VR)-based tools to enhance neurocognitive and neuromotor control assessment and treatment techniques. In the future, these types of tools will enhance provision of specialty care through telehealth, increasing access to care for the rural poor. Neurocognitive and neuromotor management, including assessment and rehabilitative treatments, are critical components of care for patients with neurological conditions and impairments. Wearable technology, integrated with telehealth, can enhance the objectivity of tests, and make treatments more accessible. The overall project has three separate co-projects, each with its own co-project leads, but provides a collaborative effort from all team members with the goal of combining neuromotor and neurocognitive assessments through novel approaches in wearable technology. Co-project #1 will attempt to validate immersive VR delivered neuro-cognitive tests with clinical test correlates through the use of functional near-infrared spectrometry to measure hemodynamic response in the large hemispheric regions of the brain in young healthy individuals. This project will also explore subject performance variability on the tests and compare differences between real-world and virtual environment test delivery. Co-project #2 will attempt to assess the efficacy of a custom-made immersive VR fall prevention neuromotor training program that provides virtual, visual postural perturbations compared to real-world treadmill-based physical postural perturbations. This will be completed among both a young healthy (18-40 years) and older adult (>60 years) population, and quantified through comprehensive biomechanical, neuromuscular, cognitive, and subjective measures. Co-Project #3 will attempt to test the efficacy of a custom-made wearable smart sock with stretch and pressure sensors capable of capturing foot and ankle kinematics and kinetics, to assess postural stability during dual-task neurocognitive examination tests in VR among older adults (>60 years). This proposed team-science project is in direct alignment with many new and ongoing strategic initiatives in Mississippi around the concept of innovation and wearable and/or medical device technologies for potential use with telehealth. In the future, these types of tools will enhance provision of specialty care through telehealth, increasing access to care for the rural poor.