# Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype

> **NIH NIH R01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $70,872

## Abstract

Project Summary/Abstract
Title: Optimizing Screening of Early-Onset Colorectal Cancer
Background: Colorectal cancer (CRC) constitutes a significant source of morbidity and mortality,
with screening playing a pivotal role in alleviating this burden. The routine incorporation of
screening colonoscopy for individuals aged 50 or older, who are at average risk, has contributed
to a notable reduction in CRC incidence and mortality, by 35% and 37% respectively.
Nevertheless, a substantial proportion of eligible individuals do not undergo screening,
contributing to 28-44% of CRC-related deaths. In the United States, disparities are evident
among Black individuals, who are more prone to being diagnosed at younger ages and in
advanced disease stages. Timely detection of CRC can significantly enhance survival by enabling
curative colonoscopy procedures. Innovative, targeted strategies for CRC prevention hold
promise for improving overall population health and mitigating CRC disparities in the U.S.
Goal: The overarching objective is to enhance the effectiveness of cancer surveillance for
individuals at risk of early-onset colorectal cancer by tailoring the surveillance approach to each
person's estimated risk of CRC incidence and mortality. This goal aims to improve the overall
well-being of patients, optimize resource allocation, and foster greater acceptance of
surveillance among both patients and healthcare providers.

## Key facts

- **NIH application ID:** 11047374
- **Project number:** 3R01CA257333-04S1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Chin Hur
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $70,872
- **Award type:** 3
- **Project period:** 2021-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11047374

## Citation

> US National Institutes of Health, RePORTER application 11047374, Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype (3R01CA257333-04S1). Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/grant/nih/11047374. Licensed CC0.

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