# Administrative Supplement - Desinging peptide macrocycles to selectively inhibit BET proteins: Martinez Noa, Yisel

> **NIH NIH R01** · UNIVERSITY OF FLORIDA · 2024 · $45,097

## Abstract

BET proteins are involved in mul3ple diseases associated with the misregula3on of immune
response genes. Through the parent grant we are characterizing the ET domain for its poten3al
as a drug target and iden3fying the origin of selec3vity across homologous ET domains. Within
this supplement we take a further step and propose the design and characteriza3on of pep3de
macrocycles as poten3al drugs using an array of computa3onal chemistry tools, which we will
later characterize with our experimental collaborators.

## Key facts

- **NIH application ID:** 11051657
- **Project number:** 3R01GM149646-02S1
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Alberto Perez
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $45,097
- **Award type:** 3
- **Project period:** 2023-06-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11051657

## Citation

> US National Institutes of Health, RePORTER application 11051657, Administrative Supplement - Desinging peptide macrocycles to selectively inhibit BET proteins: Martinez Noa, Yisel (3R01GM149646-02S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11051657. Licensed CC0.

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