# IU/JAX/PITT MODEL-AD Center: Prophylactic Treatment of Long acting GM-CSF (BBT-007) in B6.hAβsaa mice

> **NIH NIH U54** · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $397,063

## Abstract

PROJECT SUMMARY/ABSTRACT OVERALL COMPONENT
Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent
advances in our understanding of basic biological mechanisms underlying AD, we do not yet know how to prevent
AD or have an approved disease modifying intervention. Animal models of Alzheimer's disease (AD) have
provided important insights into the pathophysiology of disease and suggested potential avenues for therapies;
however, translation of these findings to the clinic has been largely unsuccessful. The MODEL-AD Consortium
was initiated to generate and validate the next generation of mouse models of late-onset Alzheimer's disease
(LOAD) as well as to perform rigorous preclinical testing of the most promising therapeutics in these models.
Based on advances in human disease characterization driven by genetic, molecular, and imaging studies, we
have created more than 40 LOAD mouse models carrying genetic risk variants. These models have been
characterized using the same molecular and imaging modalities used in the clinic, revealing LOAD-relevant
phenotypes not observed in prior mouse models. The IU/JAX/PITT MODEL-AD Center is now poised to leverage
these existing models, protocols, and data to further our mission of creating translatable preclinical tools. The
Indiana University (IU)/Jackson Laboratory (JAX)/University of Pittsburgh (IU/JAX/PITT) will leverage IU's and
PITT's strengths in neurodegenerative research including 30+ years as an NIA-supported Alzheimer's Disease
Center (ADRC) and considerable expertise in preclinical drug testing with JAX's eight decades of expertise in
mammalian genetics and disease modeling to develop, validate and disseminate new, precise animal models of
AD. In addition, the IU/JAX/PITT MODEL-AD Center contains Sage Bionetworks to provide expertise in data
organization and dissemination. The IU/JAX ADPMC brings together an international, multi-disciplinary team—
including geneticists and genetics technology experts, quantitative and computational biologists, clinical experts
in AD and neuroimaging, pharmacologists and world leaders in the development of precision animal models of
disease—that possesses the collective ability to foresee disease modeling needs as they emerge on the
international stage. This will allow the IU/JAX ADPMC to serve the AD scientific community effectively and
efficiently. Ultimately, this will accelerate the application of advances in animal models for the greatest possible
medical benefit. The Specific Aims of the IU/JAX/PITT MODEL-AD Center are:
Aim 1: Prioritize genetic variants, analyze model data, and broadly disseminate results through data
sharing and online analytics.
Aim 2: Creating and characterizing novel LOAD models
Aim 3: Screening of novel compounds through the PTC pipeline.
Aim 4: Coordinate activities within the center, the MODEL-AD consortium, and across the broader
community of AD/ADRD researchers.

## Key facts

- **NIH application ID:** 11052688
- **Project number:** 3U54AG054345-09S1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Gregory W Carter
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $397,063
- **Award type:** 3
- **Project period:** 2016-09-30 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11052688

## Citation

> US National Institutes of Health, RePORTER application 11052688, IU/JAX/PITT MODEL-AD Center: Prophylactic Treatment of Long acting GM-CSF (BBT-007) in B6.hAβsaa mice (3U54AG054345-09S1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/11052688. Licensed CC0.

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