# Center for Microbial Pathogenesis and Host Inflammatory Responses

> **NIH NIH P30** · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $766,094

## Abstract

PROJECT SUMMARY
Parent award. The initial parent award (P20-GM103625) allowed the University of Arkansas for Medical
Sciences (UAMS) to establish the Center for Microbial Pathogenesis and Host Inflammatory Responses
(CMPHIR). The scientific focus of the CMPHIR is on understanding infectious disease from the perspective of
diverse microbial pathogens and their impact on the host immunological and inflammatory responses influences
the disease process. This theme is based on the premise that understanding the complex interplay between
diverse pathogens and their common human host is a prerequisite to maximizing opportunities to manipulate
one or both sides of this equation in favor of the desired therapeutic outcome. The project is currently in Phase
III (P30-GM145393) with the goal of continuing to support and enhance the critical core facilities to support the
growing number of CMPHIR investigators, continue to provide administrative support to promote further growth
of the CMPHIR and the career development of its investigators, and promote the transition to a self-sustained
Center of Biomedical Research Excellence with the expertise and resources required to address existing and
emerging problems in infectious disease. The current proposal for a Team Science Administrative Supplement
application is directly in line with the goals of the CMPHIR and that it takes a comprehensive, team-based
approach to understanding how the crosstalk between microbiota and the host during antibiotic-induced
dysbiosis, so that new therapeutic strategies can be implemented to maintain host homeostasis and mitigate
disease risk. It is also a direct reflection of the growth of the CMPHIR in that it brings together three investigators
(one current CMPHIR P30 pilot recipient and 2 investigators with various other past COBRE and INBRE ties)
with distinct areas of expertise that can collectively take advantage of their specific strengths and cutting edge
technologies to comprehensively investigate fundamental disease-related processes of highly consequential
bacterial imbalance to an extent that otherwise would not be possible.
Research question. Antibiotic (ABX) use has significantly increased by more than 30% in recent years. Although
ABX fight infections, they also disrupt commensal microbe communities that are crucial for maintaining
homeostasis of various local and distal processes. Microbial imbalance induced by ABX, termed herein as
dysbiosis, has many systemic and long-lasting effects on the host including, but not limited to, increased risk of
vascular pathologies, e.g., solid tumors. Thus, there is a pressing need to reach a deeper understanding of the
crosstalk between microbiota and the host during dysbiosis, so that new therapeutic strategies can be
implemented to maintain host homeostasis and mitigate disease risk. The long-term overarching goal of this
supplement is to initiate a new line of investigation that brings together multiple scientific disciplines ...

## Key facts

- **NIH application ID:** 11055907
- **Project number:** 3P30GM145393-03S1
- **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS
- **Principal Investigator:** MARK S SMELTZER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $766,094
- **Award type:** 3
- **Project period:** 2022-05-05 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11055907

## Citation

> US National Institutes of Health, RePORTER application 11055907, Center for Microbial Pathogenesis and Host Inflammatory Responses (3P30GM145393-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11055907. Licensed CC0.

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