PA-20-272, Nytricx, Inc., STTR Phase II – Supplemental - Abstract “Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters" (Parent Grant 2 R42 HL149595-02A1) Nytricx has developed proprietary technology for the prevention of intravascular catheter associated thrombosis and infection, utilizing the natural properties of Nitric Oxide (NO). The combination of topcoats to prevent protein adsorption and biofilm formation, coupled with NO gas release from the base silicone polymer is unique, especially considering that the NO donor itself stays embedded in the polymer, with only NO gas escaping to affect the external and internal catheter environments. However, the silicone base polymer would not withstand power injection of contrast material which is delivered at a flow rate of 5 ml/sec to perform diagnostic CTs (computer assisted tomography). This high flow rate results in maximum pressure exerted on the catheter wall of 300 PSI.