# Defining the Role of Renal Gluconeogenesis in Renal Cell Carcinoma

> **NIH NIH R37** · YALE UNIVERSITY · 2024 · $46,921

## Abstract

PROJECT SUMMARY
Renal cell carcinoma is the most common primary kidney cancer, representing 90-95% of primary renal
neoplasms. Our work in the parent award has identified a novel liver-brain-adipose tissue-kidney
gluconeogenesis axis that drives renal cell carcinoma, driven by fibroblast growth factor (FGF)-21. While
completing studies in the parent award, we became aware that our murine models of RCC exhibit cancer
cachexia, with striking loss of skeletal muscle. Cancer cachexia is a widespread and debilitating problem, and
the work proposed in this supplement will test the hypothesis that FGF-21-driven renal gluconeogenesis
may be a key contributor to cachexia in renal cell carcinoma. The candidate, Andin Fosam, is an African
American, first generation American citizen who aims to become a physician-scientist leading a translational
research program at the intersection between oncology and preservation of functional status. The work
proposed in this supplement application will position Andin, an M.D./Ph.D. student completing her doctoral
work in the PI's lab, as a growing leader in this multifaceted area, which is in deep need of new investigators to
push the boundaries of our understanding of how physiologic principles can help avoid the devastating
consequences of cancer cachexia.

## Key facts

- **NIH application ID:** 11060836
- **Project number:** 3R37CA258261-03S1
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Rachel Jamison Perry
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $46,921
- **Award type:** 3
- **Project period:** 2024-07-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11060836

## Citation

> US National Institutes of Health, RePORTER application 11060836, Defining the Role of Renal Gluconeogenesis in Renal Cell Carcinoma (3R37CA258261-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11060836. Licensed CC0.

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