The Contractor, in performance of work under this task order, shall provide a full-service facility and staff who would support a medicinal chemistry discovery program beginning at the Exploratory Chemistry phase to develop structure activity relationship (SAR) analysis and design, synthesis, in vitro absorption, distribution, metabolism, excretion and toxicology (ADMET), computational chemistry/Computer Aided Drug Discovery (CADD) and compound logistics of storage and shipping to support the Contributor in developing a novel therapeutic to treat spinal cord injury. This will be achieved by advancing the SAR/SPR of their small molecule heterocyclic starting compound utilizing their assays and in vitro ADMET to identify novel, selective compounds for the target enzymes that are directed at Alzheimer’s Disease. The scope of this Medicinal Chemistry Support Program for Therapeutic Development (MCSP) task order shall be under Performance Area 2: Medicinal Chemistry Support in support of preclinical drug discovery efforts supported by NIH, NINDS and its Contributors, as per the Parent Contract Statement of work (SOW).