ABSTRACT Persistently impoverished neighborhoods face ongoing disinvestment, leading to significant social, environmental, and structural hurdles that impact the health outcomes of their inhabitants. The persistent poverty in these areas presents obstacles to effective cancer prevention efforts, stemming from intricate and interconnected factors that hinder prevention at the personal, healthcare system, and societal levels. Enhancing cancer outcomes in these regions necessitates innovative, cross-sectoral approaches addressing root causes and social determinants of health. It requires collaborative research and policymaking endeavors that involve the affected communities in co-creating solutions. Our supplementary proposal aims to increase the involvement of the Hmong ethnic minority in cancer-preventive screenings and broader cancer prevention efforts. This aligns with the primary focus of the main grant but complements it as there are few projects targeting this specific community. We seek to boost awareness and knowledge regarding cancer prevention among Hmong communities in California, particularly those facing persistent poverty, while encouraging their participation in early detection screenings. We will engage in community outreach by actively participating in local health fairs and other community events. Additionally, we will conduct a population assessment to identify any correlations between key social needs and colorectal cancer prevention measures. In line with the main grant's objectives, our focus will be on assessing the extent to which basic needs, such as income and access to health- improving resources like food, transportation, and housing, are met. Furthermore, we plan to utilize California cancer registries as secondary sources to examine Hmong colorectal cancer outcomes, particularly in areas marked by persistent poverty.