PROJECT SUMMARY Aligning with the NIH Strategic Plan for Data Science, the research team at Northern Arizona University (NAU), a funded Research Centers in Minority Institution, proposes to increase and sustainably support data science capacity and infrastructure at the University level. Through the first seven years of the Southwest Health Equity Research Collaborative [(SHERC), NIH U54MD012388], a strong foundation for health-equity research, contributing to NAU’s expected R1 designation in 2025, has been built. However, NAU and SHERC still lack a focus on data science. SHERC has successfully supported faculty in the use of the All of Us dataset along with the Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability initiative. The Science Collaborative for Health Disparities and Artificial Intelligence Bias Reduction (ScHARe) data platform has yet to be implemented at NAU. To further bolster the data science infrastructure at NAU, this project aims to 1) increase the data science capacity of NAU, ultimately expanding the institutional workforce, and 2) increase utilization of Big Data by health equity investigators through enhanced data science curricula, mentored training, and educational opportunities. SHERC will meet these objectives by hiring a data scientist, creating a Data Science Skills Workshop series that includes skills and knowledge needed to use the ScHARe platform, and mentoring doctoral and undergraduate students using the All of Us dataset.