# Mechanistic insight into the regulation of the apical bile acid transporter (ASBT) using chemical biology approaches

> **NIH NIH P20** · UNIVERSITY OF KENTUCKY · 2024 · $254,100

## Abstract

The proposed research is relevant to public health due to the essential role of bile acids in the regulation of lipid 
and glucose metabolism. Identification of mechanisms that modulate the stability of the human apical bile acid 
transporter may facilitate the development of innovative therapeutic strategies to restore bile acid flux and 
signaling in humans.

## Key facts

- **NIH application ID:** 11063575
- **Project number:** 5P20GM130456-05
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Lindsay Christine Czuba
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $254,100
- **Award type:** 5
- **Project period:** 2024-02-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11063575

## Citation

> US National Institutes of Health, RePORTER application 11063575, Mechanistic insight into the regulation of the apical bile acid transporter (ASBT) using chemical biology approaches (5P20GM130456-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11063575. Licensed CC0.

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