# The Tumor Microenvironment Niche of Type I conventional Dendritic Cells

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $76,956

## Abstract

PROJECT SUMMARY
This study investigates the ‘reactive’ immune system in tumors, namely the cellular and molecular allies that
allow immunotherapies to work. In particular it studies cells called ‘cDC1’. The overall hypothesis of this
proposal is that a molecule called Granulin functions to regulate immunity in tumors, through its
expression in these cells.
This program is unique in applying spatial transcriptomics together with genetic tools and conventional cellular
immunoassay methods to understand the critical phenotype-biology relationship between critical cDC
populations and their partners. The resultant discoveries will be formative for designing new ways to boost anti-
tumor immunity.

## Key facts

- **NIH application ID:** 11064353
- **Project number:** 3R01CA197363-07S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** MATTHEW F KRUMMEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $76,956
- **Award type:** 3
- **Project period:** 2023-06-21 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11064353

## Citation

> US National Institutes of Health, RePORTER application 11064353, The Tumor Microenvironment Niche of Type I conventional Dendritic Cells (3R01CA197363-07S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/11064353. Licensed CC0.

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