PROJECT SUMMARY Patient engagement in research and clinical practice holds promise for closing gaps across the substance use disorder (SUD) use and treatment cascade, yet we currently have limited understanding of best practices for patient engagement in the SUD field. We propose to engage in bioethics research to generate evidence regarding key elements of SUD patient engaged research and clinical practice, and then tailor a patient engagement framework for the SUD field. The project will result in a SUD patient engagement framework that can be disseminated, applied, and evaluated in future work.