PROJECT SUMMARY This proposal is a supplement to our existing Ola Hawaii grant, building upon the foundational work previously established under this award. Recent advancements in biomedical and health science underscore the important role of data science in deciphering complex health phenomena, facilitating access to vast datasets and uncovering underlying patterns. However, this progress also necessitates a concerted effort to bolster institutional capacity in data science to fully harness its potential. The proposed data science supplement aims to strengthen research capacity and cultivate expertise in Hawaii's biomedical and health sciences sector. Aligned with Ola HAWAII's mission, our supplement focuses on RCMI-related projects to boost their impact on health disparities research. By integrating data science into these projects, we aim to gain insights into the health challenges faced by Hawaii's diverse populations. This approach leverages the RCMI network to enhance research outcomes and understanding of health disparities. In addition to supporting ongoing research, we also seek to nurture future talent through educational and training programs with more advanced topics in data science. These efforts will include developing a comprehensive curriculum, organizing workshops, summer bootcamps, and inviting external experts to share insights with our research community. These training programs are continuous efforts based on our experiences and will cover more diverse and advanced data science topics, such as programming basics, omics data analysis, cloud computing, artificial intelligence, statistical inference, and data ethics. In summary, the proposed data science supplement represents a strategic effort to enhance research capacity, address health disparities, and foster data science expertise in Hawaii's biomedical landscape. By integrating data science support, education, and collaboration, we aim to empower researchers, drive innovation, and make significant progress in understanding and addressing health challenges in the state of Hawaii and beyond.