# Equipment and Administrative Supplement- THE HARC CENTER 2.0: HIV ACCESSORY AND REGULATORY COMPLEXES

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $500,000

## Abstract

ADMINISTRATIVE SUPPLEMENTS - THE HARC CENTER 2.0: HIV ACCESSORY AND
REGULATORY COMPLEXES
PROJECT SUMMARY
The primary goal of the HARC Center is the structural characterization of endogenous HIV-host protein
complexes involved in HIV restriction, transcription, and latency. HARC 2.0 is supported by four Technological
Cores that serve to apply and develop innovative methods for biochemical and structural characterization of
purified reconstituted complexes and dynamic endogenously purified complexes. In order to expeditiously
achieve this overall mission, the HARC Center is requesting $1,499,999 total ($1,134,084 Direct Costs;
$365,915 Indirect Costs) in supplemental funding on behalf of the Proteomics and Computational Cores and
Project 1 for (1) a critical piece of equipment, the Molecular Devices CellXpress.ai, an automated cell culture
system equipped with a cell line incubator, a liquid handler, and a high content imager ($500,000 Total Costs;
no Indirect Costs); (2) the generation of an atlas of HIV-host protein interactions, utilizing state-of-the-art
artificial intelligence tools and protein-protein interaction (PPI) mapping in primary human immune cells
($499,999 Total Costs; $305,654 Direct Costs, $194,345 Indirect Costs); and (3) the investigation of Vif
interactions with additional antiviral A3 family members ($500,000 Total Costs; $328,430 Direct Costs;
$171,570 Indirect Costs).

## Key facts

- **NIH application ID:** 11069251
- **Project number:** 3U54AI170792-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Nevan J Krogan
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $500,000
- **Award type:** 3
- **Project period:** 2024-08-22 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11069251

## Citation

> US National Institutes of Health, RePORTER application 11069251, Equipment and Administrative Supplement- THE HARC CENTER 2.0: HIV ACCESSORY AND REGULATORY COMPLEXES (3U54AI170792-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/11069251. Licensed CC0.

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