JHU Uganda CTU Administrative Supplement Request Summary The JHU Uganda HIV CTU has participated in NIH supported HIV related network treatment and Prevention trials since the mid 1990’s. The current JHU Uganda CTU organization for this 7 year cycle of NIH funding is led by three JHU PD/PIS : Dr. Mary Glenn Fowler, administrative PD/PI and Dr. Aaron Tobian PD/PI based in Baltimore; and Dr. Philippa Musoke, PD/PI based in Uganda. The JHU Uganda Clinical Research Sites (CRS) are the Baylor Uganda CRS and the Makerere U. Johns Hopkins U. (MUJHU) CRS, located on the Mulago National Hospital complex in Kampala Uganda. The current networks that the two CRSs participate in include the ACTG, IMPAACT, and HPTN. The MUJHU CRS is also completing MTN 042 trial addressing PrEP during pregnancy and has participated in a number of other MTN trials. The AIMS of the JHU Uganda CTU are to carry out HIV prevention and treatment trials; behavioral studies addressing improving adherence to PrEP and HIV treatment; vaccine and immunotherapy trials; TB prophylaxis and treatment trials; vaccines and immunotherapy trials for emerging infections; and mentoring the next generation of independent HIV researchers in Uganda. The investigators at the CTU and CRSs actively contribute to Scientific Committees of the HIV networks and support the Network research agendas. The purpose of this JHU Uganda CTU/CRS Yr 18 administrative supplement request is to further strengthen the MUJHU and Baylor Uganda CRS infrastructure in conducting the network HIV prevention and treatment trials, and to provide further technical support and training of researchers and clinical staff at the two Uganda CRSs. The supplement request includes support for both CRSs in terms of strengthening IT, administrative infrastructure; refurbishing of pharmacy and clinical facilities, and purchase of updated equipment and supplies necessary for conduct of the DAIDS network trials. In addition the administrative supplement request will also support travel to the network meetings from two Uganda CRSs; as well as travel funds for one JHU staff to make one additional site visit to the CRSs in 3rd quarter; and for one additional JHU staff member to attend the September IMPAACT meeting in Washington DC.