Project Summary/Abstract: During the progression of our study, we identified important deficiencies in our scientific plans and made necessary adjustments as quickly as possible. These deficiencies included overall patient recruitment, Hispanic patient outreach and inadequate supervision of our complex MRI data acquisition. As detailed below, we made highly needed adjustments. Overtime these changes will result in deficits that will prevent us from completing our proposed work to our high standard. We have defined an aim to address each issue and described in detail the problem and how we have addressed it. Value added and the Relation and Scope of Supplement and Parent Aims: This supplemental award promotes the high quality and success of our science by addressing unexpected problems using simple but imperative changes. As noted, we have implemented the needed changes already, but do not have the budget to adequately cover these costs. Beyond this, we have also started towards an important path of Hispanic community outreach that will benefit the Hispanic community and our current and future projects.