# GeNYC: Genomic Implementation Research in the Diverse Settings and Populations of New York City

> **NIH NIH U01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $184,191

## Abstract

Project Summary
The promise of genomic medicine to transform healthcare and improve health will not be fully realized
until discoveries become relevant to and available for use by diverse populations and their clinicians.
As part of the IGNITE II network, we are implementing two prospective randomized pragmatic
genotype-guided clinical trials (GUARDD-US and ADOPT-PGx) to determine the impact of
implementing genetic testing on hypertension, depression, and pain therapies. This administrative
supplement request is to extend the implementation timeline for these two pragmatic clinical trials by
an additional 12 months with cost to allow for completion of GUARDD-US and ADOPT PGx data
analysis, writing up of study results and closeout of all study activities. We expect the successful
results from this clinical trial will provide critical evidence needed to drive the implementation of
genomic medicine across broad demographics of patient populations.

## Key facts

- **NIH application ID:** 11074366
- **Project number:** 3U01HG010248-05S3
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Carol R Horowitz
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $184,191
- **Award type:** 3
- **Project period:** 2024-09-14 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11074366

## Citation

> US National Institutes of Health, RePORTER application 11074366, GeNYC: Genomic Implementation Research in the Diverse Settings and Populations of New York City (3U01HG010248-05S3). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/11074366. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*