ABSTRACT Alcohol misuse is one of the leading preventable health risks globally, contributing to over 60 different diseases and injuries. The associated morbidity and mortality impose a significant health and economic burden on society. Alcohol-induced end organ diseases, including alcohol-associated liver disease, cancer, pancreatitis, and others, contribute significantly to alcohol-related morbidity and mortality. These diseases often synergize with other epidemic diseases such as obesity, diabetes, and drug abuse. Despite advances in the field, the underlying disease etiology of alcohol-induced end organ diseases remains poorly understood. There is an urgent need to gain new knowledge of the molecular underpinnings to accelerate diagnosis, prevention, and treatment. This R13 proposal seeks support for the Gordon Research Conferences (GRC) on Alcohol-Induced End Organ Diseases in 2025 and 2027. The overarching goal of the GRC Alcohol-induced End Organ Diseases meetings is foster open and inclusive discussion of research developments, establish new scientific collaborations, encourage participation of diverse and underrepresented groups, and propel the next generation of scientific advances. The GRC was initiated in 2017 and has held successful meetings in 2021 (delayed to 2022) and 2023. The open format of the GRC model allows for sharing significant unpublished work and provides ample opportunities for in-depth discussions with peers, new colleagues, and the future generation of alcohol researchers. The GRC on Alcohol-Induced End Organ Diseases plays a crucial role in advancing the field by providing a platform for the dissemination of key research findings, fostering collaboration, and promoting scientific progress. The unique format of the conference ensures ample time for in-depth discussions, enabling the formulation of new approaches and the initiation of collaborations. By providing a safe and respectful forum for open discussion, the conference encourages the exchange of cutting-edge research on alcohol-induced tissue injury. The introduction of breakthrough techniques facilitates a deeper understanding of the mechanisms underlying alcohol-induced tissue injuries, paving the way for innovative approaches to diagnosis, prevention, and treatment. Moreover, the conference promotes interaction between junior and senior investigators, fostering mentorship opportunities and facilitating knowledge transfer across generations. By including scientists from disadvantaged backgrounds at all career stages, the conference ensures diverse perspectives and encourages equitable participation in the scientific community. We envision this meeting to significantly advance our understanding of the underlying mechanisms of end organ injuries and drive the development of effective therapeutic strategies for the diagnosis, prevention, and treatment of alcohol use disorders, ultimately improving health outcomes worldwide.