Abstract Summary Intra-body Wireless Sensor Link – Large Animal Testing This supplement will extend the work to develop new capabilities for the COSMIIC System by testing the intra-body wireless system in a large animal model. Two modules under current development are the “WING” and Sensor Withdrawn from A Remote Module (SWARM). These will allow for real-time feedback of physiologic data to facilitate control for closed-loop nerve stimulation algorithms. The WING module is intended to connect to wireless devices and sensors outside the body, and the SWARM is designed for connection to tethered sensors like inertial measurement units (IMUs) inside the body. Neither module, however, supports data communication from untethered sensors within the body. With this supplement, we propose to develop an intra-body wireless link that interfaces with the SWARM to enable untethered, remote sensors to connect to the COSMIIC system. This will allow the COSMIIC system to receive physiological feedback from sensors which cannot be safely accessed using wires, or from sensors that only reside in the body for limited periods. This supplement will further validate the intrabody wireless system acutely in vivo to assess accuracy of data capture when measuring physiological data (bladder pressure) in real time. Additionally, we will demonstrate triggered nerve stimulation from received data. This final proof-of-concept experiment will demonstrate that the intrabody wireless system and the COSMIIC system are feasible for closed-loop neuromodulation in future studies.