# The Gut Microbiome and The Metabolome in Chronic Kidney Disease

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $155,093

## Abstract

SUMMARY / ABSTRACT
Chronic kidney disease (CKD) may alter the homeostatic relationship between human hosts and
their intestinal tract microbial inhabitants (i.e., the gut microbiota) due to the enhanced delivery
of urea to the gut microbiota, alterations in diet, and the decrease in urinary excretion of small
molecules produced by the gut microbiota. As a result, both the composition of the gut
microbiota and its metabolite byproducts may be altered in patients with CKD. We propose a
set of inter-related specific aims to examine the association between CKD, gut microbiota and
the fecal metabolome, the plasma metabolome, and the development of clinical outcomes using
a longitudinal prospective cohort within the Chronic Renal Insufficiency Cohort (CRIC) Study.
The results of our study will provide new insights into interventions, such as modulation of diet,
that may alter the metabolome of the gut microbiota to help prevent and/or treat diseases
associated with the development of CKD.

## Key facts

- **NIH application ID:** 11075598
- **Project number:** 7R01DK107566-07
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Amanda Hyre Anderson
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $155,093
- **Award type:** 7
- **Project period:** 2024-04-22 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11075598

## Citation

> US National Institutes of Health, RePORTER application 11075598, The Gut Microbiome and The Metabolome in Chronic Kidney Disease (7R01DK107566-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/11075598. Licensed CC0.

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