ABSTRACT The JHU SSRC is an established, functioning team of multisite trial PIs, experienced lead managers, administrators, and scientists. BIOS, a JHU Clinical Trials Coordinating Center, will operationally convene this group and provide staff to execute the required Statistical and Safety Resource Center program and its specific assigned tasks in the areas of statistics, safety, and DSMB management. Our joint expertise, developing and managing trials in these specified areas extends well beyond the last five years of work on the ongoing HEAL Pain ERN studies with our group having served as clinical coordinating centers and data coordinating centers for dozens of large multi-centered clinical trials at various NIH ICs. We seek to continue our support of the awardee teams for an extended duration not originally budgeted and planned for due to the enrollment delays in POSITIVE, SKOAP, and SurgeryPal trials.