PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-030: Administrative Supplements for Contemporary Modifiable Exposures and Cancer Across the Life Course and Cancer Control Continuum. Black women are 40% more likely to die from breast cancer and twice as likely to die from cervical cancer than their White counterparts. A myriad of plausible causes for this disparity have been proposed including genetic, biological, social, and environmental factors (including contemporary modifiable exposures). The possible cumulative impacts of these factors on cancer risk among environmental justice communities has been understudied. The goal of this administrative supplement to the UPMC Hillman Cancer Center Support Grant (P30CA047904-34) is to generate preliminary data to advance our understanding of the potential cumulative impact of biological and social determinants of health and contemporary modifiable exposures to endocrine disrupting chemicals in beauty salons (e.g., chemical hair relaxers) on risk of cancer among Black women. Study findings will inform potential cancer risk reduction interventions for our Community Outreach and Engagement (COE) office and generate catchment relevant research questions among our multidisciplinary investigative team with expertise in cancer health disparities, epidemiology, environmental health, and basic science.