# Immunologic evaluation of HIV-1 HVTN experimental medicine trials HVTN 307, HVTN 309 and HVTN312

> **NIH NIH UM1** · DUKE UNIVERSITY · 2024 · $2,741,630

## Abstract

Title: Immunologic evaluation of HIV-1 HVTN experimental medicine trials HVTN 307, HVTN 309 and
HVTN312 as a supplemental application for the Duke CHAVD year 6
Barton F. Haynes, MD, CHAVD, PI
The overall hypothesis for this proposal is that deep interrogation of HVTN experimental medicine clinical
trials will provide the information needed to successfully and quickly iterate immunogen design to be able to
select for mature bnAbs in at least 1 or more bnAb B cell lineages by June 2026. The scientific premise is
that studying the frequency of bnAb precursors in blood or leukapheresis cells (naïve or memory B cells) and
LNs both after immunization with germline-targeting and then boosting immunogens will be an optimal strategy
to determine the efficacy of vaccination. We now know that Nojima cultures followed by antigen-specific paired
VH + VL sequencing with 10X genomics is a powerful and rapid way to determine the effect of vaccination with
Env immunogens on HIV bnAb precursor populations in Discovery Medicine Phase I trials. Here we propose
to bring these and other technologies to the study of the HVTN 307, HVTN 309 and HVTN 312 HIV vaccine
clinical trials and in doing so answer critical questions needed to make progress on the design of a practical
HIV vaccine.

## Key facts

- **NIH application ID:** 11078958
- **Project number:** 3UM1AI144371-06S3
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Barton F. Haynes
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,741,630
- **Award type:** 3
- **Project period:** 2019-07-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11078958

## Citation

> US National Institutes of Health, RePORTER application 11078958, Immunologic evaluation of HIV-1 HVTN experimental medicine trials HVTN 307, HVTN 309 and HVTN312 (3UM1AI144371-06S3). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/11078958. Licensed CC0.

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