# Center for Integrated Cellular Analysis - Christopher Zavala

> **NIH NIH RM1** · NEW YORK GENOME CENTER · 2024 · $18,335

## Abstract

Abstract
While rapid advances in single-cell RNA-sequencing are yielding comprehensive taxonomies of cell states in the
human body, understanding the complex molecular and environmental factors that regulate cell behavior
remains a central challenge. New methods for simultaneous measurement of multiple molecular modalities,
spatial context, and lineage relationships are needed to address this goal, but are currently outside the scope of
present technologies which largely focus on a single data type. We propose to create a Center for Integrated
Cellular Analysis, with a mission to develop a comprehensive suite of technologies and analytical methods to
measure and integrate the molecular and environmental determinants of cellular identity. To achieve these goals,
we propose the following series of synergistic Aims that will be developed in parallel: 1) Develop massively-
parallel assays to simultaneously profile multiple molecular components across millions of cells; 2) Identify
the spatial and environmental determinants of cellular state in complex interacting populations; 3) Develop
scalable platforms to profile inherited molecular components, and determine the role of cell lineage in
establishing molecular and phenotypic differences across cells; and 4) Develop methods to harmonize single-
cell profiles across distinct modalities, enabling the inference of cellular identity. Our Center will address critical
challenges in data integration, and produce software and protocols that will be applicable to diverse biological
systems. We will share these resources broadly with the community, alongside a broader educational focus to
encourage New York City students from under-represented backgrounds to pursue academic training in
Genomics and Systems Biology.

## Key facts

- **NIH application ID:** 11079002
- **Project number:** 3RM1HG011014-05S3
- **Recipient organization:** NEW YORK GENOME CENTER
- **Principal Investigator:** Dan Landau
- **Activity code:** RM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $18,335
- **Award type:** 3
- **Project period:** 2024-06-10 → 2025-09-10

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11079002

## Citation

> US National Institutes of Health, RePORTER application 11079002, Center for Integrated Cellular Analysis - Christopher Zavala (3RM1HG011014-05S3). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11079002. Licensed CC0.

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