# Administrative Supplement for U54 AI170752

> **NIH NIH U54** · DUKE UNIVERSITY · 2024 · $590,000

## Abstract

Administrative Supplement for U54 AI170752
 In the absence of an effective preventive vaccine or a cure, HIV-1 continues to be a major global health
crisis. Having claimed 40.4 million lives so far with ongoing transmission in all countries globally, according to
the World Health Organization, with some countries reporting increasing trends in new infections when
previously on the decline. For the estimated 39.0 million people living with HIV at the end of 2022, highly active
antiretroviral therapy (HAART) provides the best current hope for avoiding fatality due to the infection. While
HAART has substantially reduced morbidity and mortality, it is not curative due to the formation of a very stable
reservoir of latent virus in resting memory CD4+ T cells. The Duke Center for HIV Structural Biology (DCHSB)
brings together a diverse team of scientists to focus on structural studies of the HIV-1 Envelope (Env) protein
that provides new insights into dynamics of HIV-1 entry and fusion with the host membrane, the Env-initiated
immune activation of B cell receptors, and the role of anti-Env antibodies in blocking viral rebound.
 This multicomponent application for an Administrative Supplement for U54 AI170752, will accelerate
membrane protein technologies for HIV-1 Env studies, aimed at structural dissection of the mechanisms of
antibody interactions to the Membrane Proximal External Region (MPER), understanding HIV-1 coreceptor
tropism and elucidating the mechanism of a gp41 directed fusion inhibitor. The second component will add a
Direct Detector Camera to our existing Tundra microscope to enable routine high resolution cryo-EM data
acquisition for HIV-1 Env samples. The third component will acquire a Nanotemper Monolith X for robust
equilibrium measurement of challenging biomolecular interactions with minimal sample consumption.

## Key facts

- **NIH application ID:** 11080563
- **Project number:** 3U54AI170752-03S1
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Priyamvada Acharya
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $590,000
- **Award type:** 3
- **Project period:** 2022-06-14 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11080563

## Citation

> US National Institutes of Health, RePORTER application 11080563, Administrative Supplement for U54 AI170752 (3U54AI170752-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11080563. Licensed CC0.

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