Abstract This CFAR meeting supplement application requests funding to support the 2025 meeting of the Social and Behavioral Sciences Research Network: SBSRN 2025. The meeting will be co-hosted by the Penn and UNC CFARs and will partner with the Inter-CFAR Substance Use Research Committee and the National CFAR CAB Coalition. SBSRN 2025 will target early stage investigators (ESI) whose work integrates social and behavioral sciences in HIV prevention and treatment research. The meeting will be held in person to maximize opportunities for networking with peers from other CFARs and ARCs, established investigators, and importantly, NIH program officials. We have selected a venue in North Bethesda to increase opportunities for NIH staff to participate in both the Mentoring Day and the Scientific Symposium. The overarching goal of the meeting is to engage and energize early stage investigators working in HIV from CFARs and ARCs around the country by providing: 1) updates and insights into the NIH research priorities and application and review processes; 2) opportunities to present and receive feedback on emerging research concepts and applications being developed by participating ESI; 3) meaningful interactions with NIH program officers, senior HIV investigators, and community leaders; and, 4) presentations on cutting edge science able to inform the HIV research agenda moving forward. Beginning in 2006, the SBSRN met annually through 2018 and again in 2022. Over this time, attendance averaged between 100 and 150 participants, and the meeting consistently received very positive evaluations, particularly among the 259 ESI who participated as mentees. The SBSRN meeting has become a highly valued, shared resource for CFARs around the country. It is uniquely focused on promoting transdisciplinary HIV research among behavioral scientists from a variety of disciplines and places a high priority on personal interactions among behavioral, clinical, and basic science investigators, NIH program officials, and ESI, particularly those from under-represented racial and ethnic groups. The provisional theme of the proposed meeting is “The Role of Behavioral and Social Scientists in Getting to Zero.” Funds will be used to cover the cost of the meeting venue and travel for ESI and selected speakers.