# Core A: Husbandry & Management Core

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $1,346,834

## Abstract

Core A – Husbandry and Management Core: Project Summary
ONPRC Expanded SPF (eSPF) rhesus macaques (Macaca mulatta) are defined as being negative for
rhesus rhadinovirus, simian immunodeficiency virus, simian foamy virus, simian T-lymphotropic virus, simian
retrovirus, macacine herpesvirus-1, measles, and rhesus cytomegalovirus. They are critical for the study of
opportunistic viruses impacting HIV infected patients. eSPF macaques are a premier animal model for
HIV/AIDS research, including studies on HIV pathogenesis, AIDS-related opportunistic infections, and the
development of HIV treatments and vaccines. With the rapid expansion of infectious disease research
programs, the national need for genetically characterized eSPF rhesus macaques for HIV/AIDS research
continues to exceed current availability. It is imperative that the available eSPF rhesus macaque colonies
continue to expand to support this research and the advancement of human health. The successful
maintenance of eSPF colonies requires strict barrier management practices in order to remain specific
pathogen free. With over 22 years' experience in maintaining a colony of eSPF animals, the ONPRC is a
leader in managing eSPF rhesus macaques. The overall aims of the Husbandry and Management Core are
to expand the ONPRC eSPF breeding colony to meet existing and future animal resource demands,
continue to refine existing exemplary eSPF husbandry and veterinary care, and to diversify the eSPF
resource by increasing successful recruitment of genetically valuable animals in our breeding colony. To
ensure the continued success of this program, we will utilize a collaborative, team-based approach to
management practices including further expansion of the colony into outdoor sheltered housing,
diversification of the time- mated breeding program, stable male/female pairs, assisted reproductive
techniques, growth of the foster dam program for abandoned infants, and rederivation of infants from the
ONPRC SPF4 colony.

## Key facts

- **NIH application ID:** 11084016
- **Project number:** 2U42OD023038-09A1
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Cassandra Cullin
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,346,834
- **Award type:** 2
- **Project period:** 2016-08-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11084016

## Citation

> US National Institutes of Health, RePORTER application 11084016, Core A: Husbandry & Management Core (2U42OD023038-09A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11084016. Licensed CC0.

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