# Core C: MHC Genetic Typing Core

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $102,580

## Abstract

Core C - MHC Genetic Typing Core: Project Summary
Rhesus macaques (Macaca mulatta) are a vital non-human primate (NHP) model for the study of infectious
disease and are in critically high demand for biomedical research studies. The expanded Specific Pathogen
Free (eSPF) colony at the Oregon National Primate Research Center (ONPRC) is an essential resource for the
production of model macaques free from an extended list of pathogens capable of confounding the study of
human immunodeficiency virus and the related simian immunodeficiency virus (HIV/SIV) pathogenesis. These
purpose-bred animals are crucial for meeting the growing demand for NHP research animals and to facilitate
advancements in human health. Accurate and comprehensive genetic analysis of the eSPF colony is essential
to its long-term health and the continued productivity in generating valuable research animals. Of critical
importance is the genotyping of the major histocompatibility complex (MHC) which can strongly influence host
response to infection and must be accounted for in study design and data analysis. MHC loci are highly
polymorphic and structurally complex, requiring specialized assays and analysis procedures for accurate and
comprehensive genetic characterization. The MHC Genetic Typing Core (Genetics Core) is responsible for
genetic testing and analysis of the eSPF colony and works closely with individual investigators and the
Husbandry and Management Core to ensure that research and colony management needs are met.
Additionally, the Genetics Core assays genetic variation within the population using multiple metrics to promote
adequate genomic diversity through the use of parentage confirmation, ancestry testing, and the genotyping of
specific pathogenic variants or alleles capable of influencing pathogenic response. ONPRC is a leader in the
development and use of genomic technologies in NHP research and the Genetics Core will utilize state-of-the-
art tools and incorporate the use of novel resources to support the goals of the eSPF colony.

## Key facts

- **NIH application ID:** 11084018
- **Project number:** 2U42OD023038-09A1
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Samuel Peterson
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $102,580
- **Award type:** 2
- **Project period:** 2016-08-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11084018

## Citation

> US National Institutes of Health, RePORTER application 11084018, Core C: MHC Genetic Typing Core (2U42OD023038-09A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/11084018. Licensed CC0.

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