Dissecting spinal interneuron circuits to augment neurological recovery in Degenerative Cervical Myelopathy (DCM)

NIH RePORTER · NIH · R01 · $23,111 · view on reporter.nih.gov ↗

Abstract

PROJECT ABSTRACT: This is an application for a Research Supplement to Promote Diversity in Health-Related Research for the parent grant, “Dissecting spinal interneuron circuits to augment neurological recovery in Degenerative Cervical Myelopathy (DCM)” (R01NS134644). DCM is a debilitating neurological condition caused by progressive compression of the spinal cord, resulting in a wide range of devastating symptoms like loss of fine motor function, compromised gait, sensory impairment, and chronic pain. The primary goal of the parent grant is to understand and define the neural circuitry affected by DCM to develop strategies that improve patient functional outcomes. The aims of the parent grant examine the anatomical and functional role of Dorsal type-3 interneurons (dI3 INs) on forelimb function and plasticity in DCM and recovery. This diversity supplement request is for Ms. Allison Brezinski, a highly qualified and ambitious PhD candidate whose long-term goal is to become an independent neuroscience investigator. The research aims of this supplement examining dI3 interneurons in the role of respiratory ability in DCM expand on the research within the parent grant and will provide Ms. Brezinski an invaluable opportunity to lead and execute an independent research project. The training and experience provided will hone her leadership skills while also expanding her expertise in neural circuits and neurological disorders. Under this supplement, Ms. Brezinski will have full access to the co-investigators of the multi- institutional parent grant to develop her networking skills and expand her scientific network for future collaborations. Altogether, the award and completion of this supplement will be a crucial step in Ms. Brezinski’s career and support her goal of becoming an independent academic researcher.

Key facts

NIH application ID
11088648
Project number
3R01NS134644-01S1
Recipient
MEDICAL COLLEGE OF WISCONSIN
Principal Investigator
Kajana Satkunendrarajah
Activity code
R01
Funding institute
NIH
Fiscal year
2024
Award amount
$23,111
Award type
3
Project period
2024-03-01 → 2026-11-30