Pediatric Dose Optimization for Seizures in EMS (PediDOSE)

NIH RePORTER · NIH · U01 · $50,825 · view on reporter.nih.gov ↗

Abstract

PROJECT SUMMARY / ABSTRACT Equitable care for children with seizures is critical to optimize well-being and health outcomes; however, little is known about existing health inequities in the emergency management and outcomes of children who are experiencing a seizure. Identifying areas of inequitable care in the emergency management of pediatric seizures at the patient and community levels in both the prehospital and emergency department settings can inform future work to determine root causes, interventions, and the development of policies to improve equitable care. Through this diversity supplement we aim to expand the aims of the parent grant by evaluating associations with risk factors for receiving inequitable care and the management and short-term outcomes of pediatric patients experiencing a seizure. The parent grant is a 20-site stepped wedge trial of standardized, age-based midazolam dosing administration for children in the Emergency Medicine Services (EMS) setting who are experiencing a seizure. Aim 1 of the supplement will evaluate the association between patient-level risk factors for receiving inequitable health care and social determinants of health with the frequency of seizure activity on emergency department (ED) arrival for pediatric patients transported by EMS for seizures. Aim 2 will evaluate the association between patient-level risk factors for receiving inequitable healthcare and social determinants of health with prehospital care, ongoing participation in research, ED interventions, and short-term outcomes. We hypothesize that both individual-level demographics and social determinants of health will be associated with increased frequency of seizures on arrival to the ED, need for additional interventions in the prehospital and ED settings, and worse short-term outcomes. The diversity supplement candidate will serve as the principal investigator of these aims conducted in a multi-site prospective clinical trial, will gain an in-depth understanding of conducting health equity research in the prehospital setting, and will develop hypotheses for further research on reducing health inequities in this population.

Key facts

NIH application ID
11089217
Project number
3U01NS114042-03S1
Recipient
STANFORD UNIVERSITY
Principal Investigator
Manish Ishwar Shah
Activity code
U01
Funding institute
NIH
Fiscal year
2024
Award amount
$50,825
Award type
3
Project period
2021-08-01 → 2026-11-30