Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.

NIH RePORTER · NIH · R44 · $99,011 · view on reporter.nih.gov ↗

Abstract

Project Summary/Abstract At Magnetic Tides we developed a radically new NIBS approach, one in which subthreshold modulation of neural excitability is brought about via oscillating magnetic fields at kilohertz frequencies. This system, referred to kTMP (kilohertz Transcranial Magnetic Perturbation) significantly increases the range of subthreshold E-field induction, and through modulation of the envelope of the kHz carrier frequency, can impose E-fields at physiological relevant frequencies. In the parent grant, the initial experiments are conceived to test tolerability and efficacy of kTMP in healthy participants, leading to behavioral experiments which focus on improving motor skills with kTMP. The goal of the supplement research projects are focused on training the supplementee Ms. Ahmad-Ali (trainee level: pre-doctoral) in a bioengineering project focused on create a setup that enables detailed measurements of performance during a motor task involving fine and gross movements (Aim1); in parallel, the supplementee will help the leadership team to perform an engineering gap analysis to clearly document the technological characteristics of kTMP by establish a Formal Design History File (Aim 2). The supplementee intends to pursue a career path focused on regulation of biomedical device development. At this stage in her career her main goal is to gain hands-on experience in a company that is setting the stage to launch a medical device to the market. By the time her appointment ends, the candidate will gain extensive experience in technology development and, additionally, she will acquire in-depth understanding of the regulatory paperwork required to sell a medical device.

Key facts

NIH application ID
11090181
Project number
3R44NS127667-03S3
Recipient
MAGNETIC TIDES, INC.
Principal Investigator
Ludovica Labruna
Activity code
R44
Funding institute
NIH
Fiscal year
2024
Award amount
$99,011
Award type
3
Project period
2022-08-15 → 2026-07-31