ABSTRACT Background: Escalating rates of childhood obesity have become a global health crisis, with significant impacts on long-term health. Approximately 19.2% of children in the United States are now affected by obesity. Returning genetic risk scores for obesity is an innovative approach to obesity intervention that may help improve prevention and management. This project examines the effects of communicating genetic risk information to parents regarding childhood obesity and its potential psychosocial impact, perceived value, and expected response to relevant recommendations. Objectives: The parent electronic medical records and genomics (eMERGE) program is returning to each of >4000 pediatric participants a Genomic Informed Risk Assessment (GIRAs) for obesity plus three other conditions (asthma, type 1 diabetes, type 2 diabetes). Approximately 140 children will receive a GIRA indicating high risk for obesity. The primary objective of this supplement is to evaluate how the disclosure of genetic risk information impacts parents' perceptions, psychological responses, and behavioral intentions concerning management of their children's weight. Methods: Semi-structured interviews will be conducted to explore parental responses to the genetic risk information. Interviewees are parents or guardians of three sub-cohorts: 1) obese child (per electronic health record (EHR)) with HR obesity [N=15], 2) non-obese child (per EHR) with a HR obesity GIRA [N=15], and 3) obese child (per parent report and EHR) whose GIRA does not indicate HR for obesity [N=30]. Themes related to understanding the genetic information, psychosocial impacts, and behavioral intentions will be identified through thematic analysis. Expected Results: We anticipate identifying a spectrum of parental responses, from motivated health behavior changes to feelings of anxiety and guilt about their child's predisposition to obesity. The study will provide insights into the effectiveness of genetic information in fostering behavior change and the psychological impact of such disclosures on parents. Conclusion: This research will enhance our understanding of the role of genetic risk information in managing childhood obesity. It will contribute to the development of guidelines and interventions that effectively use genetic information to support health-promoting behaviors, while also considering relevant ethical implications. Relevance: The findings from this study will inform best practices in genetic counseling and pediatric healthcare, specifically addressing the ethical, psychological, and practical considerations of disclosing genetic risks to parents. This is essential for developing interventions that not only prevent obesity but also minimize potential psychological distress associated with genetic risk communication.