# Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa

> **NIH NIH D43** · DANA-FARBER CANCER INST · 2024 · $35,600

## Abstract

PROJECT SUMMARY/ABSTRACT
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as
“NOT-CA-24-039.”
Cancer mortality rates are projected to more than double in Sub-Saharan Africa (SSA) in the next two decades.
This public health crisis requires that a knowledge base be developed to better understand and act on the
growing cancer burden in SSA. We propose a training program that will maximize the rigor of cancer research
in SSA by training researchers to develop strategic and operational capacity that will generate new knowledge
about the determinants of cancer risk and outcomes and improve effectiveness of strategies for reducing risk
and improve outcomes. The overarching goals of this training program are to 1) Develop and disseminate best
practices to enable the highest quality cancer research in Africa; 2) Teach fundamental skills to those who
conduct research in Africa; and 3) Create a cadre of individuals who can lead and support cancer research in
SSA. Our training program proposes the following specific aims: 1) Develop and implement an educational and
career development program that will maximize the rigor of research being conducted in SSA; 2) Recruit and
train individuals who can build sustainable careers in cancer research; 3) Assess the impact of this training
program on the career outcomes of trainees and participants. Trainees will fall into two groups. First, we propose
a Principal Investigator (PI) Track for doctoral level investigators who will be trained to demonstrate leadership
in independent and collaborative research. Participants in the PI Track will become proficient in research
oversight and governance and build the skills and a scientific project focus toward independent extramural grant
funding. Second, a Project Management (PM) Track will be implemented to support the conduct of research.
Participants in the PM Track will be qualified to support a variety of research projects within SSA health and
regulatory settings. Training will involve bilateral interactions between mentors and trainees in both SSA and the
US who will partner to develop and implement best research practices. The training program will build on highly
successful existing research networks in SSA: The African Breast Cancer Study (ABCS), The African
Esophageal Cancer Consortum (AFRECC), The African Research Group in Oncology (ARGO), and the Men of
African Descent and Carcinoma of the Prostate (MADCaP) network. Building on mentors and research capacity
of these networks, the proposed program will provide a core research curriculum known as the PROject
Management Oversight Training and Education in AFRICA (PROMOTE-AFRICA) framework as well as project-
based (for the PI Track) or practicum-based (for the PM track) activities as well as other educational experiences
to individuals seeking careers as independent cancer researchers or project managers.

## Key facts

- **NIH application ID:** 11092452
- **Project number:** 3D43CA260640-04S1
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** TIMOTHY RICHARD REBBECK
- **Activity code:** D43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $35,600
- **Award type:** 3
- **Project period:** 2024-09-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11092452

## Citation

> US National Institutes of Health, RePORTER application 11092452, Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa (3D43CA260640-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11092452. Licensed CC0.

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