# Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls

> **NIH NIH K23** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $54,000

## Abstract

Risk for major depressive disorder (MDD) onset dramatically increases during adolescence, particularly for girls.
There is a vital need to elucidate the underlying mechanisms of MDD risk to improve early risk detection and
targeted preventions. The stress generation model posits interpersonal stress generation (I-StressGen) as a
mechanism of risk and proposes that youth with preexisting MDD vulnerabilities actively contribute to the
occurrence of interpersonal stressful life events in their lives (i.e., I-StressGen), which in turn exacerbates their
risk for MDD. Although the impact of I-StressGen on prospective MDD risk in adolescents is well-established,
the precise mechanisms contributing to I-StressGen remain unclear. Self-report research indicates increased
affective reactivity during negative social interactions as a promising mechanism contributing to I-StressGen,
though this has not been directly tested. The underlying neural mechanisms of I-StressGen also remain
unexamined, despite work suggesting that greater social stress is associated with aberrant activation in
corticolimbic regions during tasks probing response to negative social interactions. Therefore, the overarching
goal of the proposed study is to obtain a fine-grained, mechanistic understanding of the role of brain and
behavioral affective reactivity during negative social interactions as it relates to I-StressGen and subsequent
MDD risk in female adolescents. The proposed study will enroll a risk-enhanced sample of 90 female adolescents
(ages 13-15) and will utilize neuroimaging (fMRI) and ecological momentary assessment (EMA) to examine brain
and behavior indices of socio-affective reactivity as predictors of I-StressGen and depression symptoms across
a multi-wave one year follow-up. In doing so, the current study will test whether affective reactivity during negative
social interactions at the neural (Aim 1) and real-world behavioral (Aim 2) level prospectively predicts I-
StressGen, and whether I-StressGen mediates the relation between this socio-affective reactivity and
prospective increases in female adolescents’ depression symptoms (Aim 3). The proposed study and parallel
training plan will allow the Candidate to build upon her current expertise in adolescent stress and MDD risk and
develop new skills in four key areas: (1) fMRI, (2) EMA, (3) advanced statistical multilevel modeling, and (4)
professional development. The rich academic environment at the University of Illinois at Chicago coupled with
the collective expertise of the Candidate’s mentorship team in fMRI methodology, developmental affective
neuroscience, EMA, and advanced statistical techniques will facilitate successful implementation of the proposed
study and training plan. The acquisition of these skills will be integral to launching the Candidate’s independent
career as a translational scientist focused on delineating brain-behavioral mechanisms of adolescent MDD risk
within the context of real-world inte...

## Key facts

- **NIH application ID:** 11092599
- **Project number:** 3K23MH129564-03S1
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Cope Feurer
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $54,000
- **Award type:** 3
- **Project period:** 2022-09-15 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11092599

## Citation

> US National Institutes of Health, RePORTER application 11092599, Brain-Behavioral Predictors of Interpersonal Stress Generation and Depression Risk in Adolescent Girls (3K23MH129564-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/11092599. Licensed CC0.

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