# The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions

> **NIH NIH UF1** · UNIVERSITY OF PENNSYLVANIA · 2024 · $2,065,898

## Abstract

PROJECT SUMMARY
This application requests funds to refine and rigorously test a collaborative care model for patients with opioid
use disorder (OUD) and major depression, post-traumatic stress disorder, or an anxiety disorder in primary
care. We also will examine clinician and practice characteristics associated with successful implementation
and the cost effectiveness of different care models. The primary aims of this proposal are: (1) Rapidly
prototype and test each element of our collaborative care models to optimize it for implementation; (2) Conduct
a randomized study of three collaborative care conditions with 39 practices to determine which is most
effective in improving outcomes for people with OUD and mental health conditions: (a) Augmented Usual Care:
PCP waivered to prescribe buprenorphine and mental health care manager, (b) Collaborative Care: Waiver
PCP; mental health care manager receives OUD training; practice receives telephonic psychiatric consultation,
or (c) Collaborative Care + Social Worker to address social determinants of health; (3) Measure clinician and
organizational-level factors associated with implementation of each component, with the goal of developing
strategies to increase successful implementation; (4) Conduct a cost evaluation of each collaborative care
model; and (5) Work with smaller and more rural practices to develop and test effective strategies to manage
OUD. Successful completion of the proposed study will provide definitive evidence regarding the most
parsimonious set of elements of integrated collaborative care required to maximize outcomes for individuals
with OUD and psychiatric disorders. Because of the study design, our examination of implementation factors,
and our community partnerships, the results also will have high probability of adoption and implementation.

## Key facts

- **NIH application ID:** 11092954
- **Project number:** 4UF1MH121944-02
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** HILLARY R BOGNER
- **Activity code:** UF1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,065,898
- **Award type:** 4N
- **Project period:** 2019-09-12 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11092954

## Citation

> US National Institutes of Health, RePORTER application 11092954, The Whole Health Study: Collaborative Care for OUD and Mental Health Conditions (4UF1MH121944-02). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/11092954. Licensed CC0.

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