# Molecular Basis and Regulatory Mechanisms of Exosome Secretion

> **NIH NIH R35** · UNIVERSITY OF PENNSYLVANIA · 2024 · $48,176

## Abstract

ABSTRACT
Exosomes are small extracellular vesicles secreted by cells. Exosomes carry bioactive molecules such as
signaling proteins and mRNAs, and potently affect the pathophysiology of their recipient cells. The project funded
by my R35 grant “Molecular Basis and Regulatory Mechanisms of Exosome Secretion” (R35 GM141832) aims
to understanding the molecular mechanisms that control the biogenesis and secretion of exosomes, and the
regulation of exosome biogenesis by oncogenic signaling. A combination of molecular biology and biochemistry
approaches were proposed to understand exosome secretion at the molecular level. Molecular cloning and
protein analysis will be performed through the project. In this proposal, supplement fund is requested for the
purchase of a Bio-Rad documentation system to replace our broken and outdated unit. This is a basic piece of
equipment for the capture and storage of the images of nucleotide acid and protein gels, and is indispensable
for the accomplishment of the goals proposed in the parent R35 grant.

## Key facts

- **NIH application ID:** 11093625
- **Project number:** 3R35GM141832-04S1
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** WEI GUO
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $48,176
- **Award type:** 3
- **Project period:** 2021-05-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/11093625

## Citation

> US National Institutes of Health, RePORTER application 11093625, Molecular Basis and Regulatory Mechanisms of Exosome Secretion (3R35GM141832-04S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/11093625. Licensed CC0.

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